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Recombinant Mouse CD252/OX40L/TNFSF4 Protein, His Tag

Protein

Recombinant Mouse CD252/OX40L/TNFSF4 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD252

TNFSF4 (TNF Superfamily Member 4) is a Protein Coding gene. Diseases associated with TNFSF4 include Myocardial Infarction and Systemic Lupus Erythematosus. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding.Cytokine that binds to TNFRSF4.Co-stimulates T-cell proliferation and cytokine production.

 

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Product Background

OX40 ligand(OX40L), also called CD252, is a single-pass type II membrane protein of the TNF/TNF receptor superfamily. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. OX40L–OX40 co-stimulation leads to activation of TNF receptor associated factor(TRAF) 2, 3 and 5. This pathway has been shown to prolong the survival of effector CD4+Th cells as well as contributes to generation of memory T cells.

Product Specification

Catalog Number

ALP64621

Product Name

Recombinant Mouse CD252/OX40L/TNFSF4 Protein, His Tag

Alias

Tumor necrosis factor ligand superfamily member 4, OX40L

Alternate Names

cd252,ox40l,ox40l protein,ox40l ene,tnfsf4,tnfsf4 elisa,tumor necrosis factor ligand superfamily member 4,CD252 Protein,tnfsf4 Protein,Recombinant CD252 Protein,Recombinant ox40l Protein,Recombinant tnfsf4 Protein,mouse tnfsf4 elisa,Mouse CD252 Protein,Recombinant Protein,his tag,his tag protein

Official Symbol

CD252/OX40L/TNFSF4

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

TNF Superfamily

Product Description

ALP64621 Recombinant Mouse CD252 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Ser51-Leu198 is expressed with a 8His tag at the N-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Vu, M. D., Xiao, X., Gao, W., et al., Blood, 2007, DOI: 10.1182/blood-2006-12-061358

2 Murata, K., Nose, M., Ndhlovu, L. C., et al., Blood, 2002, DOI: 10.1182/blood-2002-02-0438

3 Weinberg, A. D., Vella, A. T., Cytokine Growth Factor Reviews, 2001, DOI: 10.1016/S1359-6101(00)00028-2

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