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Recombinant Mouse CD270/HVEM/TNFRSF14 Protein, Fc Tag

Protein

Recombinant Mouse CD270/HVEM/TNFRSF14 Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD270

TNFRSF14 (TNF Receptor Superfamily Member 14) is a Protein Coding gene. Diseases associated with TNFRSF14 include Herpes Simplex and Herpetic Whitlow. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor receptor activity. An important paralog of this gene is TNFRSF11A.Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network.Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation.Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes.  

 

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Product Background

Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T(Teff) cells and regulatory T cells(Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. It has demonstrated that HVEM Ig is able to exert a significant antiviral effect against HSV-1 infection in vivo.

Product Specification

Catalog Number

ALP64639

Product Name

Recombinant Mouse CD270/HVEM/TNFRSF14 Protein, Fc Tag

Alias

Tumor Necrosis Factor Receptor Superfamily Member 14, CD270

Alternate Names

cd270,hvem gene,hvem,hvem protein,mouse hvem elisa,tnfrsf14,mouse tnfrsf14 elisa,tnfrsf14 elisa,cd279 protein,Recombinant Protein,fc tag,fc tag protein,Mouse CD270 Protein

Official Symbol

CD270/HVEM/TNFRSF14

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64639 Recombinant Mouse CD270 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Gln39-Val207 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 van Mierlo, G. J., & van Lier, R. A, Immunology and Cell Biology, 2011, DOI: 10.1038/icb.2011.3

2 Alderson, M. R., & Armitage, R. J., Immunity, 1996, DOI: 10.1016/S1074-7613(00)80236-1

3 Grumont, R. J., & Gerondakis, S., Journal of Immunology, 2001, DOI: 10.4049/jimmunol.166.11.6619

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