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Recombinant Mouse CD275/B7-H2/ICOSL Protein, His Tag

Protein

Recombinant Mouse CD275/B7-H2/ICOSL Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD275

ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Combined Immunodeficiency and Combined T And B Cell Immunodeficiency. Among its related pathways are CD28 Signaling in T-Helper Cell and Immune response NFAT in immune response. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is CD276.Ligand for the T-cell-specific cell surface receptor ICOS.Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). 

 

Alpha Lifetech follows strict quality control principles to ensure that our recombinant proteins meet standards of purity, efficacy, and consistency.

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Product Background

Mouse ICOS ligand(B7-H2) is an approximately transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is expressed on antigen presenting cells such as B cells, macrophages, monocytes, and dendritic cells. It binds to ICOS on activated T cells, leading to both positive and negative effects on immune responses including its own down-regulation. The B7-H2 interaction with ICOS is costimulatory for T cell proliferation as well as the development of B cells, plasma cells, follicular helper T cells and germinal centers. B7-H2 contributes to the development of allergic asthma by enhancing Th2 biased immune responses, limiting Th17 responses, and promoting eosinophilic infiltration into the lung. Its activation of ICOS on Treg limits pulmonary inflammation and airway hyperresponsiveness, promotes the development of inhalational tolerance, and impairs antitumor immunity. In the thyroid, B7-H2 is up-regulated on thyrocytes during inflammation and promotes their proliferation and production of thryoid hormones.

Product Specification

Catalog Number

ALP64591

Product Name

Recombinant Mouse CD275/B7-H2/ICOSL Protein, His Tag

Alias

B7 homolog 2, B7-H2

Alternate Names

cd275,b7-h2,mouse b7-h2,icosl,icosl gene,icosl protein,CD275 protein,b7-h2 protein,Recombinant Protein,Mouse CD275 Protein,his tag,his tag protein

Official Symbol

CD275/B7-H2/ICOSL

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

B7 family

Product Description

ALP64591 Recombinant Mouse CD275 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Glu47-Lys279 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A., Nature, 1999, DOI: 10.1038/74047

2 Coyle, A. J., Lehar, S., Lloyd, C., Tian, J., Delaney, T., Manning, S., ... & Gutierrez-Ramos, J. C., Immunity, 2000, DOI: 10.1016/S1074-7613(00)80027-9

3 Wang, S., Zhu, G., Chapoval, A. I., Dong, H., Tamada, K., Ni, J., & Chen, L., Blood, 2000, DOI: 10.1182/blood.V96.8.2808

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