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Recombinant Mouse CD40L/TNFRSF5 Protein, His Tag

Protein

Recombinant Mouse CD40L/TNFRSF5 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD40LR

CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Cd40 Ligand Deficiency. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and CD40 receptor binding. An important paralog of this gene is TNFSF10.Cytokine that acts as a ligand to CD40/TNFRSF5.Costimulates T-cell proliferation and cytokine production.Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation.

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand(CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins(adaptor proteins) have been identified to serves as mediators of the signal transduction. CD40 plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

Product Specification

Catalog Number

ALP64585

Product Name

Recombinant Mouse CD40L/TNFRSF5 Protein, His Tag

Alias

Tumor Necrosis Factor Receptor Superfamily member 5, CD40L

Alternate Names

cd40l,scd40l elisa,mouse cd40l,cd40l protein,recombinant cd40l,cd40l gene,mouse tnfrsf5 elisa,tnfrsf5 protein,Recombinant Protein,Mouse CD40L Receptor Protein

Official Symbol

CD40L/TNFRSF5

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

TNF Receptor Superfamily

Product Description

ALP64585 Recombinant Mouse CD40L Receptor Protein, His Tag is produced in HEK293 Cells and the target gene encoding Leu20-Arg193 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 van Essen, D., Kikutani, H., & Gray, D., Immunology Today, 1995, DOI: 10.1016/0167-5699(95)80059-4

2 Kornbluth, R. S., & Stone, G. W., Clinical and Experimental Immunology, 2006, DOI: 10.1111/j.1365-2249.2006.03015.x

3 Banchereau, J., & Steinman, R. M., Nature, 1998, DOI: 10.1038/25261

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