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Recombinant Mouse CD47/MER6 Protein, Fc Tag

Protein

Recombinant Mouse CD47/MER6 Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD47

CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Hemolytic Anemia. Among its related pathways are Innate Immune System and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity.Adhesive protein that mediates cell-to-cell interactions.Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins.Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation.

 

Scientists at Alpha Lifetech have expertise in protein engineering, and with extensive expertise in protein engineering, we provide optimized recombinant proteins that enhance stability and functionality.

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Product Background

CD47, also known as Integrin-Associated Protein(IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain(ECD) with a single Ig-like domain, five membrane-spanning regions with short intervening loops, and C-terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important role in memory formation and synaptic plasticity in the hippocampus. As a receptor for SIRPA, it binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cellcell adhesion, it enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. It may play a role in membrane transport and/or integrin dependent signal transduction. It also prevents premature elimination of red blood cells.

Product Specification

Catalog Number

ALP64623

Product Name

Recombinant Mouse CD47/MER6 Protein, Fc Tag

Alias

Leukocyte Surface Antigen CD47, MER6

Alternate Names

cd47,cd47 gene,cd47 inhibitor,cd47 protein,recombinant cd47,cd47 ligand,cd47 receptor,Mouse CD47 Protein,Recombinant Protein,fc tag,fc tag protein

Official Symbol

CD47/MER6

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

SHPS/SIRP Family

Product Description

ALP64623 Recombinant Mouse CD47 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Gln19-Pro158 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Oldenborg, P. A., Leukemia & Lymphoma, 2004, DOI: 10.1080/1042819042000207554

2 Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P., Mitra, S. S., ... & Weissman, I. L., Proceedings of the National Academy of Sciences, 2012, DOI: 10.1073/pnas.1121623109

3 Majeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., ... & Weissman, I. L., Cell, 2009, DOI: 10.1016/j.cell.2009.06.045

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