English
Leave Your Message
Recombinant Mouse CD48/SLAMF2 Protein, His Tag

Protein

Recombinant Mouse CD48/SLAMF2 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD48

CD48 (CD48 Molecule) is a Protein Coding gene. Diseases associated with CD48 include Lymphoproliferative Syndrome, X-Linked, 1 and Macs Syndrome. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Gastric cancer network 2. Gene Ontology (GO) annotations related to this gene include signaling receptor activity and antigen binding. An important paralog of this gene is SLAMF8.Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation.Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex.In turn, promotes LCK phosphorylation and subsequent activation. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

Products Categories
Featured Products
recommended service
quick links
Contact Us

Product Background

CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. Among dendritic cells(DC), CD48 is selectively expressed on circulating myeloid DC and resident bone marrow and thymus DC. CD2, 2B4, and heparan sulfate function as CD48 ligands. CD48 is competent to transduce signals and can also trigger signaling through CD2 or 2B4. CD48 expressed on NK cells is coactivating, whereas CD48 expressed on other cell types inhibits NK cell activation.

Product Specification

Catalog Number

ALP64581

Product Name

Recombinant Mouse CD48/SLAMF2 Protein, His Tag

Alias

SLAM Family Member 2, CD48

Alternate Names

cd48,cd48 gene,cd48 marker,mouse cd48,cd48 elisa,mouse cd48 elisa,Recombinant Protein,his tag,his tag protein,Mouse CD48 Protein

Official Symbol

CD48/SLAMF2

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64581 Recombinant Mouse CD48 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Phe23-Arg216 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Bottino, C., Castriconi, R., Moretta, L., & Moretta, A. (2004). Cellular ligands of activating NK receptors. Trends in Immunology, 25(5), 285-291. DOI: 10.1016/j.it.2004.03.008

2 Liu, Y., & Eisenbarth, S. C. (2020). CD48: A co-stimulatory molecule regulating interactions between immune cells in inflammatory diseases, cancer, and infections. Frontiers in Immunology, 11, 614925. DOI: 10.3389/fimmu.2020.614925

3 Perez-Quintero, L. A., Roncagalli, R., Guo, H., Latour, S., & Davidson, D. (2014). EAT-2 and ERT molecules regulate activating receptor–dependent NK cell functions through phospholipase Cγ1. Journal of Immunology, 192(3), 875-884

FAQ

Leave Your Message