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Recombinant Mouse CD86/B7-2 Protein, His Tag

Protein

Recombinant Mouse CD86/B7-2 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD86

CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Plague and Cowpox. Among its related pathways are CD28 co-stimulation and PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and coreceptor activity. An important paralog of this gene is CD80.Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4.May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation.Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

T-lymphocyte activation antigen CD86(B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. Mouse CD86 shares 59% and 81% aa sequence identity with human and rat CD86, respectively. It contains 1 Ig-like C2-type domainand 1 Ig-like V-type domain. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.

Product Specification

Catalog Number

ALP64565

Product Name

Recombinant Mouse CD86/B7-2 Protein, His Tag

Alias

T-lymphocyte activation antigen CD86, CD86

Alternate Names

cd86,cd86 marker,cd86 mouse,cd86 gene,mouse cd86,cd86 protein,Mouse CD86 Protein,b7-2,mouse b7-2 elisa,b7-2 protein,Recombinant Protein,his tag,his tag protein

Official Symbol

CD86/B7-2

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64565 Recombinant Mouse CD86 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Val24-Lys244 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Carreno, B. M., & Collins, M., Annual Review of Immunology, 2002, DOI: 10.1146/annurev.immunol.20.091301.131129

2 Lenschow, D. J., Walunas, T. L., & Bluestone, J. A., Annual Review of Immunology, 1996, DOI: 10.1146/annurev.immunol.14.1.233

3 Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A., Nature, 1999, DOI: 10.1038/74047

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