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Recombinant Mouse Gi24/B7-H5/VISTA Protein, His Tag

Protein

Recombinant Mouse Gi24/B7-H5/VISTA Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: Gi24

VSIR (V-Set Immunoregulatory Receptor) is a Protein Coding gene. Diseases associated with VSIR include Hard Palate Cancer and Ocular Cancer. Among its related pathways are NF-kappaB Signaling and T cell modulation in pancreatic cancer. An important paralog of this gene is IGSF11.Immunoregulatory receptor which inhibits the T-cell response.May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity).May stimulate MMP14-mediated MMP2 activation. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

Mouse Platelet receptor Gi24(VISTA) is a transmembrane glycoprotein with homology to B7like immune costimulatory molecules. Mature mouse Gi24 contains a 159 amino acid(aa) extracellular domain(ECD) with one V-type Ig-like domain, a 21 aa transmembrane segment, and a 97 aa cytoplasmic domain. VISTA promotes both MT1-MMP expression and the MT1-MMP mediated activation of MMP-2. It supports the differentiation of embryonic stem cells(ESC) and enhances BMP-4 induced signaling in ESC, but it is also down-regulated following BMP-4 exposure. It binds to BMP-4 directly and also associates with the type I BMP receptor Activin RIB/ALK-4. It is expressed on the surface of na-ve CD4+ T cells and regulatory T cells. It is up-regulated in vivo on activated monocytes and dendritic cells. VISTA inhibits CD4+ and CD8+ T cell proliferation and their production of IL-2 and IFN-γ. Its expression on tumor cells attenuates the antitumor immune response and enables more rapid tumor progression.

Product Specification

Catalog Number

ALP64593

Product Name

Recombinant Mouse Gi24/B7-H5/VISTA Protein, His Tag

Alias

Platelet receptor Gi24, Gi24

Alternate Names

vista immune checkpoint,vista gene,vista target,vista protein,vista ligand,vista mouse,Gi24 protein,B7-H5 protein,Recombinant Protein,Mouse Gi24 Protein,his tag,his tag protein

Official Symbol

Gi24/B7-H5/VISTA

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64593 Recombinant Mouse Gi24 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Phe33-Ala191 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Lines, J. L., Pantazi, E., Mak, J., Sempere, L. F., Wang, L., O'Malley, Y., ... & Noelle, R., Cancer Research, 2014, DOI: 10.1158/0008-5472.CAN-14-0112

2 Wang, L., Rubinstein, R., Lines, J. L., Wasiuk, A., Ahonen, C., Guo, Y., ... & Noelle, R. J., Journal of Experimental Medicine, 2011, DOI: 10.1084/jem.20100619

3 Le Mercier, I., Lines, J. L., Noelle, R. J., & Wang, L., Frontiers in Immunology, 2015, DOI: 10.3389/fimmu.2015.00258

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