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Recombinant Mouse VTCN1/B7-H4 Protein, Fc Tag

Protein

Recombinant Mouse VTCN1/B7-H4 Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: VTCN1

VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1) is a Protein Coding gene. Diseases associated with VTCN1 include Renal Cell Carcinoma and Pancreatic Cancer. Among its related pathways are NF-kappaB Signaling and T cell modulation in pancreatic cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is BTNL8.Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity.When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity.Involved in promoting epithelial cell transformation.  

 

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Product Background

Mouse V-set domain-containing T-cell activation inhibitor 1/VTCN1/B7-H4 is glycosylated member of the B7 family of immune co-stimulatory proteins. B7-H4 consists of extracellular domain(ECD) with one Ig-like V-set domain and one Ig-like C2-set domain. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.

Product Specification

Catalog Number

ALP64594

Product Name

Recombinant Mouse VTCN1/B7-H4 Protein, Fc Tag

Alias

T cell costimulatory molecule B7x, VTCN1

Alternate Names

vtcn1,b7-h4,b7-h4 gene,vtcn1 protein,b7-h4 protein,Recombinant Protein,Mouse VTCN1 Protein

Official Symbol

VTCN1/B7-H4

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

B7 Costimulatory Protein Family

Product Description

ALP64594 Recombinant Mouse VTCN1 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Leu25-Ser256 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Podojil, J. R., & Miller, S. D., Current Opinion in Investigational Drugs, 2005, DOI: 10.1016/j.coi.2005.08.013

2 Vincek, V., Clark, S. H., Glickman, L. T., & Dayan, A. D., Veterinary and Comparative Oncology, 2007, DOI: 10.1111/j.1476-5829.2007.00183.x

3 Kryczek, I., Wei, S., Zou, L., Zhu, G., Mottram, P., Xu, H., ... & Zou, W., Journal of Experimental Medicine, 2006, DOI: 10.1084/jem.20050930

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