English
Leave Your Message
slide1

RESOURCE

Learn about service protocol, methods and technologies

CONTACT US
01

Resource Center

RESEARCH AREAS

Immunology

Alpha Lifetech-1mvtAlpha Lifetech-2(1)esa
01

What is immunology?

b8nz5

Immunology is a discipline that studies the immune system and is a very important branch of medicine and biological sciences. Immunology is a relatively new science. Its origin is usually attributed to Edward Jenner, who discovered in 1796 that cowpox or vaccinia can prevent smallpox in humans, a usually fatal disease. Jenner referred to his program as vaccination, a term still used to describe healthy individuals receiving a weakened or attenuated strain of a pathogen to provide disease protection.


What Is the Content of Immunological Research?

Studying various aspects of the immune system in all living organisms, immunology can help understand the physiological functions of the immune system in both healthy and diseased states; The dysfunction of the immune system in immune diseases such as autoimmune diseases, hypersensitivity reactions, immune deficiencies, and transplant rejection; And the physical, chemical, and physiological characteristics of immune system components in vitro, in situ, and in vivo.

Why Is Immunology Important?

From Edward Jenner’s pioneering work in the 18th Century that would ultimately lead to vaccination in its modern form (an innovation that has likely saved more lives than any other medical advance), to the many scientific breakthroughs in the 19th and 20th centuries that would lead to, amongst other things, safe organ transplantation, the identification of blood groups, and the now ubiquitous use of monoclonal antibodies throughout science and healthcare, immunology has changed the face of modern medicine. Immunological research continues to extend horizons in our understanding of how to treat significant health issues, with ongoing research efforts in immunotherapy, autoimmune diseases, and vaccines for emerging pathogens, such as Ebola. Advancing our understanding of basic immunology is essential for clinical and commercial application and has facilitated the discovery of new diagnostics and treatments to manage a wide array of diseases. In addition to the above, coupled with advancing technology, immunological research has provided critically important research techniques and tools, such as flow cytometry and antibody technology.

Types of Immune System

Innate Immune System

Immune System fights against microbes and prevent their entry inside the body. Innate Immune System is composed of cells and proteins that are always present and are ready to fight against microbes in the infection area. Innate Immune System is present from the time of our birth.


Table 1. Important components of the innate immune response and their functions

Components of Innate Immunity Function
1 Epithelial cells Act as barrier to infection
2 Complement proteins Circulating proteins that can induce a variety of inflammatory response to pathogens
Select Cells of Innate Immunity Function
1 Monocytes May differentiated into macrophages or monocytes in response to infection, neoplastic disease, or inflammation
2 Macrophages Migrates from blood vessels into tissues, consumption of pathogens and cancerous cells by phagocytosis, may present antigens to activate the adaptive immune response
3 Dendritic cell Presents antigens on its surface resulting in activation of the adaptive immune response
4 Neutrophils Represent 50%–60% of circulating leukocytes, release products to kill pathogens, stimulate immune response
5 Natural killer cell Possess cell-killing ability, can destroy tumor cells and cells infected with viruses

Alpha Lifetech-3(1)hro

Adaptive Immune System

The adaptive immune system is required to fight against pathogens that cannot be controlled by innate immune defences. It is also referred to as the acquired immune system because it is acquired during the course of life. They are specific to the type of pathogen invading the body. All the components of the adaptive immune system are generally inactive however when activated these components adjust to the presence of all the infectious agents by proliferating and developing a potent mechanism for eliminating the microbes. Two Types of adaptive responses are – humoral immunity moderated by antibodies which are developed by B lymphocytes and cell-mediated immunity, moderated by T Lymphocytes.

Table 2. Adaptive immunity and functioning of the different types of lymphocytes



Types of Lymphocytes
Function
1 B lymphocyte Production of antibodies, neutralization of microbes, facilitates phagocytosis
2 Helper CD4+ T lymphocyte Activates a variety of other cell types (B lymphocytes, other T lymphocytes, including cytotoxic T lymphocytes, macrophages) and mediates inflammatory response
3 Cytotoxic CD81 T lymphocyte Kills infected or neoplastic cells
4 Regulatory T lymphocytes (regulatory T cells) This is a subset of CD41 lymphocytes that inhibits the immune response

Applications of Immunology

Immunology is widely used in numerous disciplines, including medicine, in the fields of organ transplantation, bacteriology, oncology, virology, parasitology, rheumatic diseases, psychiatric disorders, and dermatology. The Immunology of transplantation mainly deals with the process of transplantation from a donor to the recipient, so that the recipient’s body does not reject the organ.

Reference
Lawrence Kashat, Christopher H. Le, Alexander G. Chiu, The Role of Targeted Therapy in the Management of Sinonasal Malignancies, Otolaryngologic Clinics of North America, Volume 50, Issue 2, 2017, Pages 443-455, https://doi.org/10.1016/j.otc.2016.12.016.
Syed NI. 2021 Editor's Choice Articles in the Section "Cells of the Nervous System". Cells. 2022 Nov 28;11(23):3802. doi: 10.3390/cells11233802. PMID: 36497062; PMCID: PMC9735456.
Pandya, Sharnil, Aanchal Thakur, Santosh Saxena, Nandita Jassal, Chirag Patel, Kirit Modi, Pooja Shah, Rahul Joshi, Sudhanshu Gonge, Kalyani Kadam, and et al. 2021. "A Study of the Recent Trends of Immunology: Key Challenges, Domains, Applications, Datasets, and Future Directions" Sensors 21, no. 23: 7786. https://doi.org/10.3390/s21237786
https://en.wikipedia.org/